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Human-specific cartilage changes and joint-disease risk

Update 1 of 1LatestNov 15, 6:53 AM UTCDay 1
Human cartilage has less water-holding sugar. Genes offer a clue why
A human–ape comparison links altered gene regulation to lower levels of cartilage’s water-holding GAGs. How much that contributes to osteoarthritis remains unresolved.
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Earliest sourceHayadan - HayadanOct 1, 6:33 AM UTC
What we knew first
- 8Joint types with lower human GAG levels
- 42Human cartilage donors reported by researchers
- 7Great-ape individuals in the tissue comparison

Who reported

Who reported

15 outlets · 19 sources

1 of 15 had reported by this moment

jpost.comFirst to reportjpost.com · Nov 14, 10:48 AM UTC1
1. Israeli study finds why humans suffer from joint pain while apes stay agile - The Jerusalem PostNov 14 UTC
Naturenature.com3
PubMed Central (PMC)nih.gov3
GitHubgithub.com1
1. GokhmanLabOrganization/the_gene_regulatory_evolution_of_the_human_skeleton
Hayadan - Hayadanhayadan.com1
1. The Evolution of Cartilage: Why Human Joints Are Prone to ErosionOct 1 UTC
McGill Law Journalmcgill.ca1
1. What makes us human? A first atlas of functional DNA changes offers new clues | Newsroom - McGill University
PLOSplos.org1
1. Xylosyltransferase-I Regulates Glycosaminoglycan Synthesis during the Pathogenic Process of Human Osteoarthritis | PLOS One
Technion - Israel Institute of Technologytechnion.ac.il1
1. The gene-regulatory evolution of the human skeleton

Who's involved

Who's involved

People

David Gokhmanresearcher
Fumitaka Inoueresearcher (ORCID 0000-0003-0657-434X)
Yizhi Yanresearcher (ORCID 0000-0003-4054-3125)

Organizations

Kyoto Universitynational university located in Kyoto, Japan
NatureBritish scientific journal since 1869
Weizmann Institute of Scienceresearch institute in Rehovot, Israel

Places

Kyoto
Rehovot